Drug-induced Gingival Enlargement in a Liver transplant patient
김성진, 김익환, 이고은, 강정민,
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김성진 ( Kim Seong-Jin ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
김익환 ( Kim Ik-Hwan ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
이고은 ( Lee Ko-Eun ) - Kyung Hee University School of Dentistry Department of Pediatric Dentistry
강정민 ( Kang Chung-Min ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
KMID : 1144020210170020050
Abstract
Drug-induced gingival enlargement is an abnormal growth of the gingiva due to adverse drug reaction in patients treated with immunosuppressants, calcium channel blockers, and anticonvulsants. Especially a correlation between phenytoin, nifedipine, cyclosporine and gingival enlargement are found to be evident. A 7-year-old boy came to the Department of Pediatric Dentistry, Yonsei University Dental hospital for gingival overgrowth. He has been taking tacrolimus and amlodipine due to a history of liver transplant and hypertension. Clinical examination revealed generalized severe gingival enlargement in the region of maxillary and mandibular teeth. Panoramic view showed increased thickness of gingiva up to incisal 1/3 portion of mandibular anterior teeth. As there were risks in invasive procedures due to immunosuppressive drugs, regular dental check-up with scaling had been done for a year. At the age of eight, scalpel gingivectomy was performed in both maxilla and mandible under general anesthesia. Gingival enlargement induced by tacrolimus alone is rare, but when taken with calcium channel blocker it might have synergistic effect. The correlation between patient’s periodontal health status with gingival enlargement as well as systemic effect has also been proved, therefore maintaining good oral hygiene would be an important factor to reduce the risk for recurrence.
키워드
Drug-induced gingival enlargement; Immunosuppressive drug; Calcium channel blocker; Gingivectomy
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